University of Calgary researcher Dr. Jeff Dunn is interviewed about new technology developed by the university to detect and monitor concussions. (Jeff McIntosh/The Canadian Press)

Scientists use MRIs to curb use of rats, mice in medical research

Researchers use a small MRI to test possible treatments for cancer, strokes and multiple sclerosis

Medical scientists at the University of Calgary have taken steps to minimize the impact on mice and rats used in their experiments.

The university’s Cumming School of Medicine is outfitted with a small MRI that researchers use as they test possible treatments for cancer, strokes and multiple sclerosis.

“It’s one of the premier ones in Canada,” said Jeff Dunn, director of the school’s Experimental Imaging Centre.

“Anything under 500 grams fits in there, so mostly rats and mice. We use those in medical research obviously for preclinical assessment, how the disease progresses and possibly even more importantly if the treatment is functional.”

The MRI has been in use since 2004. The lab is also equipped with a blood gas analyzer, so tests can be done using blood samples taken from the animals in much the same way they are collected from human patients.

It’s a far cry from when scientists would use rats and mice and have to dissect them at every test stage.

“It really reduces the use of animals in research because, for a time-course study of treatment, we don’t have to do a whole bunch of animals,” Dunn said.

“You can take a small number and follow them over months to see how the treatment is working.”

READ MORE: Animal rights group appeals B.C. court decision over euthanized bear cub

Any research facility receiving government funding is subject to rules set out by the Canadian Council on Animal Care.

Spokeswoman Sandra MacInnis says the organization wants to ensure animal-based science in Canada takes place only when necessary and that the animals receive optimal care.

“For example, when selecting a research model, they must first consider all possible alternatives to animal models, such as computer or cell-culture models,” she wrote in an email.

The executive director of the Vancouver-based Animals in Science Policy Institute says efforts by the University of Calgary and others to use the equipment are a matter of debate.

Elisabeth Ormandy, a former researcher, said putting a mouse under an MRI scanner requires sedation or anesthesia and could be considered a source of distress for an animal since it could happen several times.

“It depends on our own personal ethics,” Ormandy said. “For people who care about that one individual mouse, that (MRI) might still not be OK.”

But she said some people might argue “it’s better to cause a little bit more suffering to one mouse instead of moderate suffering to 10 mice.”

An animal rights organization said there’s no need to use animals in tests at all when computer modelling can be just as useful.

“All things else being equal, certainly hurting and killing fewer animals is better than hurting and killing more animals,” said Jeremy Beckham, research associate with People for the Ethical Treatment of Animals.

But he said that loses the bigger question a little bit.

“There’s not any real basis to think they feel pain any less than, say, a dog or a cat,” Beckham said.

“We’ve bred dogs and cats to be our companions, so we’ve got a little bit more of an emotional attachment to them. But the ethical issues of using rats and mice are staring us in the face just as strongly.”

Bill Graveland, The Canadian Press

Like us on Facebook and follow us on Twitter.

Just Posted

15 new mayors to take office across the Kootenays

Here’s a look at the highlights from across the Kootenay region in B.C.

Mayoral results from across B.C.

Voters in 162 municipalities in B.C. set to elect mayor, council, school board and more

Every vote counts: 10 tightest races in B.C.’s municipal elections

Peachland saw their election decided by just one vote

Don McCormick re-elected as Mayor of Kimberley

Election results are in, McCormick to serve as Mayor for another four terms.

Polls closed, Kimberley City Council announced

Sandra Roberts, Nigel Kitto, Kent Goodwin, Darryl Oakley, Kyle Dalum and Jason McBain elected.

Don McCormick re-elected as Mayor of Kimberley

Election results are in, McCormick to serve as Mayor for another four terms.

B.C. Youtuber to seal himself ‘in a jar’ to demonstrate impacts of climate change

Kurtis Baute wants to see how long he can last in a 1,000 cubic foot, air-tight greenhouse

One of Taiwan’s fastest trains derails, killing at least 18

The train was carrying more than 360 people

Scheer marks one-year countdown to federal election with campaign-style speech

Conservative Leader insists that it will be Justin Trudeau who ‘makes it personal’

Canada Post union announces rotating strikes in four Canadian cities

Mail will still be delivered but it will be delayed

B.C. VIEWS: Residents have had enough of catering to squatters

Media myth of homeless victims offends those who know better

B.C. man sets new Canadian marathon record at Toronto Waterfront Marathon

Cam Levins ran it in two hours nine minutes 25 seconds

B.C. Liberals’ hopes high as Nanaimo by-election approaches

Historically safe NDP seat vacated by long-time MLA Leonard Krog

Leaving B.C.’s electoral reform to a referendum is ‘ridiculous’: professor

B.C. voters getting ballots in the mail on proposal to change electoral system

Most Read